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IMMUNOGLOBULIN VARIABLE REGION
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DeCS
Descriptor
English
:
Immunoglobulin Variable Region
Descriptor
Spanish
:
Región Variable de Inmunoglobulina
Descriptor
Portuguese
:
Região Variável de Imunoglobulina
Synonyms
English
:
Variable Region, Ig
Variable Region, Immunoglobulin
Tree Number:
D12.644.541.500.650.500
D12.776.124.486.485.680.650.500
D12.776.124.486.485.797
D12.776.124.790.651.680.650.500
D12.776.124.790.651.797
D12.776.377.715.548.680.650.500
D12.776.377.715.548.797
G02.111.570.060.425
Definition
English
:
That region of the immunoglobulin molecule that varies in its
amino acid sequence
and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (
COMPLEMENTARITY DETERMINING REGIONS
) and framework regions.
Pharmacological Action:
Immunologic Factors
See Related
English
:
Binding Sites, Antibody
History Note
English
:
84(77); was see under BINDING SITES, ANTIBODY 1977-83
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22209
Unique Identifier:
D007135
Occurrence in VHL
:
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DeCS
CID-10
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